一、个人简介

陈士林，中国工程院院士、中国医学科学院学部委员，现任学院首席教授、香港浸会大学荣誉教授。兼任 CGCM（中药全球化联盟）副主席、中国质量协会中药分会会长、日本东京药科大学客座教授；为教育部“长江学者和创新团队计划”创新团队负责人，曾任中国医学科学院药用植物研究所所长、中国中医科学院中药研究所所长等。担任 APSB、Chinese Medicine、CHM、《药学学报》等刊副主编。获得第二届全国创新争先奖章。

陈士林为本草基因组学学科创始人，创建了基于 ITS2 的中草药DNA 条形码鉴定方法体系，完成专著《中国药典中药材 DNA 条形码标准序列》，从基因层面解决中草药物种真伪鉴定的难题，被评为 2016中国十大医学进展；通过全基因组解析提出灵芝为首个中药基原药用模式真菌，被 Nature China 选为中国最佳研究亮点推介；完成并发表人参、丹参、赤芝、菊花、卷柏、穿心莲、紫芝、紫苏、黄连、红豆杉等全基因组图谱和相关组学研究，成功培育并获批 11 个中药材新品种证书或良种证书。主编《本草基因组学》并由科学出版社出版，列为全国高等医药院校规划教材；出版《药用植物分子遗传学》，奠定药用植物分子遗传学基础；完成并编著《中国中药材产地生态适宜性数值区划》，避免中药材盲目引种栽培。获吴阶平医药创新奖、Agilent Thought Leadership Award、诺奖之星等荣誉；获国家科技进步二等奖 3 项。

发表论文 500 余篇，包括国际著名期刊 Nature Plants,NatureCommunications，PNAS 等，论文被引用 3.2 万次。H 指数 86 (GoogleScholar)，入选 Elsevier 公布的全球终身科学影响力榜单。

二、近期主要论文

1. Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, CanWang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, ZhigangHu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, ZhaoyuLiu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen*. Cepharanthine analogs mining andgenomes of Stephania accelerate anti-coronavirus drug discovery. Nature Communications. 2024 Feb 20;15(1):1537.

2. Wei Sun, Qinggang Yin, Huihua Wan, Ranran Gao, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, CaixiaWang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, PengSun, Xuehua Xie, Zhigang Hu, David R Nelson, Zhichao Xu, XinxiaoSun, Shilin Chen*. Characterization of the horse chestnut genomereveals the evolution of aescin and aesculin biosynthesis. Nature Communications. 2023 Oct 13;14(1):6470.

3. Wei Chen, Chi Song, Liang Leng, Sanyin Zhang, Shilin Chen*. TheApplication of Artificial Intelligence Accelerates G Protein-CoupledReceptor Ligand Discovery[J]. Engineering, 2024, 32(1):19-29.

4. Sijie Sun, Xiaofeng Shen, Yi Li, Ying Li, Shu Wang, Rucan Li, Huibo Zhang, Guoan Shen, Baolin Guo, Jianhe Wei, Jiang Xu, Benoit St-Pierre, Shilin Chen*, Chao Sun. Single-cell RNAsequencing provides a high-resolution roadmap for understanding themulticellular compartmentation of specialized metabolism. Nature plants, 2023 Jan; 9(1):179-190.

5. Baosheng Liao, Xiaofeng Shen, Li Xiang, Shuai Guo, Shiyu Chen, Ying Meng, Yu Liang, Dandan Ding, Junqi Bai, Dong Zhang, TomaszCzechowski, Yi Li, Hui Yao, Tingyu Ma, Caroline Howard, ChaoSun, Haitao Liu, Jiushi Liu, Jin Pei, Jihai Gao, Jigang Wang, XiaohuiQiu, Zhihai Huang, Hongyi Li, Ling Yuan, Jianhe Wei, Ian Graham, Jiang Xu, Boli Zhang, Shilin Chen*. Allele-aware chromosome-levelgenome assembly of Artemisia annua reveals the correlation betweenADS expansion and artemisinin yield. Mol Plant. 2022 Aug1;15(8):1310-1328.

6. Yujun Zhang, Qi Shen, Liang Leng, Dong Zhang, Sha Chen, YuhuaShi, Zemin Ning, Shilin Chen*. Incipient diploidization of themedicinal plant Perilla within 10, 000 years, Nature Communications, volume12, Article number:5508(2021).

7. Shilin Chen*, Jiang Xu, Chang Liu, Yingjie Zhu, David R Nelson, Shiguo Zhou, Chunfang Li, Lizhi Wang, Xu Guo, Yongzhen Sun, Hongmei Luo, Ying Li, Jingyuan Song, Bernard Henrissat, AnthonyLevasseur, Jun Qian, Jianqin Li, Xiang Luo, Linchun Shi, Liu He, Li Xiang, Xiaolan Xu, Yunyun Niu, Qiushi Li, Mira V Han, HaixiaYan, Jin Zhang, Haimei Chen, Aiping Lv, Zhen Wang, MingzhuLiu, David C Schwartz, Chao Sun. Genome sequence of the modelmedicinal mushroom Ganoderma lucidum. Nature Communications. 2012 Jun 26;3:913.

8. Yifei Liu, Bo Wang, Shaohua Shu, Zheng Li, Chi Song, Di Liu, Yan Niu, Jinxin Liu, Jingjing Zhang, Heping Liu, Zhigang Hu, Bisheng Huang, Xiuyu Liu, Wei Liu, Liping Jiang, MohammadMurtaza Alami, Yuxin Zhou, Yutao Ma, Xiangxiang He, YichengYang, Tianyuan Zhang, Hui Hu, Michael S Barker, Shilin Chen*, Xuekui Wang, Jing Nie. Analysis of the Coptis chinensis genomereveals the diversification of protoberberine-type alkaloids. Nature Communications. 2021 Jun 2;12(1):3276.

9. Shilin Chen, Jingyuan Song, Chao Sun, Jiang Xu, Yingjie Zhu, Rob Verpoorte, Tai Ping Fan.Herbal genomics: Examining the biologyof traditional medicines. Science 2015, 347(6219), S27-S29.

10. China Plant BOL Group, De-Zhu Li, Lian-Ming Gao, Hong-Tao Li, Hong Wang, Xue-Jun Ge, Jian-Quan Liu, Zhi-Duan Chen, Shi-LiangZhou, Shi-Lin Chen, Jun-Bo Yang, Cheng-Xin Fu, Chun-Xia Zeng, Hai-Fei Yan, Ying-Jie Zhu, Yong-Shuai Sun, Si-Yun Chen, Lei Zhao, Kun Wang, Tuo Yang, and Guang-Wen Duan.Comparative analysisof a large dataset indicates that internal transcribed spacer (ITS) shouldbe incorportated into the core barcode for seed plants. PNAS, 2011, 108:19641-19646.